Probiotic milk has been previously demonstrated to reduce the number of respiratory infections (RI) among children attending day care centres. Thus, this pilot study was aimed to assess the efficacy and the safety of 3 month treatment with Bacillus clausii in the prevention of recurrent respiratory infections (RRI) in children. Eighty children with RRI were studied: 40 of them were randomly treated with B. clausii for 3 months, and followed up for further 3 months; 40 were included in the control group during the same period. Children treated with B. clausii had shorter duration of RI in comparison with the control group both during the treatment phase (mean 11.7 days vs 14.37; p=0.037) and the follow-up period (mean 6.6 days vs 10.92; p=0.049). This effect was evident also in allergic children during the follow-up. In conclusion, this pilot study provides the first preliminary evidence that B. clausii may exert a significant and persistent impact on RI in children and is safe and well tolerated.
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机译：以前已证明益生菌奶可以减少进入日托中心的儿童的呼吸道感染（RI）数量。因此，该初步研究旨在评估克劳氏芽孢杆菌治疗3个月预防儿童反复呼吸道感染（RRI）的功效和安全性。对80例RRI儿童进行了研究：其中40例接受克劳氏芽孢杆菌随机治疗3个月，并随访3个月。同期有40例被纳入对照组。在治疗阶段（平均11.7天vs. 14.37； p = 0.037）和随访期间（平均6.6天vs. 10.92； p = 0.049），接受克劳氏芽孢杆菌治疗的儿童的RI持续时间均比对照组短。 。在随访期间，这种效应在过敏儿童中也很明显。总之，这项初步研究提供了第一个初步证据，表明克劳氏芽孢杆菌可对儿童的RI产生重大而持久的影响，并且安全且耐受性良好。
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